United States - Champions
| A. J. | Foyt | 7 | 1960 USAC, 1961 USAC, 1963 USAC, 1964 USAC, 1967 USAC, 1975 USAC, 1979 USAC |
| Rick | Mears | 6 | 1979 CART, 1981 CART, 1982 CART, 1984 USAC, 1988 USAC, 1991 USAC |
| Mario | Andretti | 4 | 1965 USAC, 1966 USAC, 1969 USAC, 1984 CART |
| Al | Unser | 4 | 1970 USAC, 1983 CART, 1985 CART, 1987 USAC |
| Bobby | Rahal | 4 | 1986 CART, 1986 USAC, 1987 CART, 1992 CART |
| Al | Unser, Jr. | 3 | 1990 CART, 1992 USAC, 1994 CART |
| Earl | Cooper | 3 | 1913 AAA, 1915 AAA, 1917 AAA |
| Jimmy | Bryan | 3 | 1954 AAA, 1956 USAC, 1957 USAC |
| Tom | Sneva | 3 | 1977 USAC, 1978 USAC, 1983 USAC |
| Louis | Meyer | 3 | 1928 AAA, 1929 AAA, 1933 AAA |
| Ted | Horn | 3 | 1946 AAA, 1947 AAA, 1948 AAA |
| Sam | Hornish, Jr. | 3 | 2001 IRL, 2002 IRL, 2006 IRL |
| Bobby | Unser | 2 | 1968 USAC, 1974 USAC |
| Johnny | Rutherford | 2 | 1980 CART, 1980 USAC |
| Rodger | Ward | 2 | 1959 USAC, 1962 USAC |
| Ralph | DePalma | 2 | 1912 AAA, 1914 AAA |
| Tony | Bettenhausen | 2 | 1951 AAA, 1958 USAC |
| Ralph | Mulford | 2 | 1911 AAA, 1918 AAA |
| Jimmy | Murphy | 2 | 1922 AAA, 1924 AAA |
| Danny | Sullivan | 2 | 1985 USAC, 1988 CART |
| Josef | Newgarden | 2 | 2017 INDYCAR, 2019 INDYCAR |
| Peter | DePaolo | 2 | 1925 AAA, 1927 AAA |
| Rex | Mays | 2 | 1940 AAA, 1941 AAA |
| Wilbur | Shaw | 2 | 1937 AAA, 1939 AAA |
| Joe | Leonard | 2 | 1971 USAC, 1972 USAC |
| Michael | Andretti | 1 | 1991 CART |
| Gordon | Johncock | 1 | 1976 USAC |
| Tommy | Milton | 1 | 1921 AAA |
| Eddie | Hearne | 1 | 1923 AAA |
| Johnnie | Parsons | 1 | 1949 AAA |
| Jimmy | Vasser | 1 | 1996 CART |
| Buddy | Lazier | 1 | 2000 IRL |
| Ryan | Hunter-Reay | 1 | 2012 INDYCAR |
| Scott | Sharp | 1 | 1996 IRL |
| Harry | Hartz | 1 | 1926 AAA |
| Bill | Cummings | 1 | 1934 AAA |
| Mauri | Rose | 1 | 1936 AAA |
| Roger | McCluskey | 1 | 1973 USAC |
| Greg | Ray | 1 | 1999 IRL |
| Sam | Hanks | 1 | 1953 AAA |
| Bob | Sweikert | 1 | 1955 AAA |
| Chuck | Stevenson | 1 | 1952 AAA |
| Howdy | Wilcox | 1 | 1919 AAA |
| Ray | Harroun | 1 | 1910 AAA |
| Kelly | Petillo | 1 | 1935 AAA |
| Tony | Stewart | 1 | 1996-97 IRL |
| Billy | Arnold | 1 | 1930 AAA |
| George | Robertson | 1 | 1909 AAA |
| Bob | Carey | 1 | 1932 AAA |
| Henry | Banks | 1 | 1950 AAA |
| George | Snider | 1 | 1981-82 USAC |
| Buzz | Calkins | 1 | 1996 IRL |
| Floyd | Roberts | 1 | 1938 AAA |
| Buck | Baker | 1 | 1952 NASCAR |
| Louis | Schneider | 1 | 1931 AAA |
| Pete | Allen | 1 | 1953 NASCAR |