Firestone Grand Prix of St.
Petersburg
St. Petersburg Street Circuit
1.8 Mile Street Course
100 Laps/180 Miles
April 25, 2021
| Finish | Start | Driver | Car # | Sponsor/Name | Chassis | Engine | Laps | Status | Points |
| 1 | 1 | Colton Herta | 26 | Gainbridge | Dallara UAK 18 | Honda | 100 | 1:51:51.4115 96.552 | 54 |
| 2 | 3 | Josef Newgarden | 2 | Hitachi | Dallara UAK 18 | Chevy | 100 | 1:51:53.9048 96.516 | 40 |
| 3 | 4 | Simon Pagenaud | 22 | Australian Gold | Dallara UAK 18 | Chevy | 100 | 1:51:57.5611 96.464 | 36 |
| 4 | 2 | Jack Harvey | 60 | AutoNation/SiriusXM | Dallara UAK 18 | Honda | 100 | 1:51:59.4948 96.436 | 32 |
| 5 | 8 | Scott Dixon | 9 | PNC Bank | Dallara UAK 18 | Honda | 100 | 1:52:00.3612 96.423 | 30 |
| 6 | 15 | Takuma Sato | 30 | Shield Cleansers/Panasonic | Dallara UAK 18 | Honda | 100 | 1:52:03.0917 96.384 | 28 |
| 7 | 16 | Marcus Ericsson | 8 | Huski Chocolate | Dallara UAK 18 | Honda | 100 | 1:52:03.3508 96.381 | 26 |
| 8 | 20 | Will Power | 12 | Verizon 5G | Dallara UAK 18 | Chevy | 100 | 1:52:04.6478 96.362 | 24 |
| 9 | 7 | Rinus VeeKay | 21 | Autogeek | Dallara UAK 18 | Chevy | 100 | 1:52:05.1309 96.355 | 22 |
| 10 | 5 | Sébastien Bourdais | 14 | ROKiT | Dallara UAK 18 | Chevy | 100 | 1:52:07.4066 96.322 | 20 |
| 11 | 14 | Scott McLaughlin | 3 | DEX Imaging | Dallara UAK 18 | Chevy | 100 | 1:52:09.0041 96.300 | 19 |
| 12 | 17 | Felix Rosenqvist | 7 | Vuse/Arrow Electronics | Dallara UAK 18 | Chevy | 100 | 1:52:09.9753 96.286 | 18 |
| 13 | 18 | Romain Grosjean | 51 | Nurtec ODT | Dallara UAK 18 | Honda | 100 | 1:52:14.1391 96.226 | 17 |
| 14 | 13 | Ryan Hunter-Reay | 28 | DHL | Dallara UAK 18 | Honda | 100 | 1:52:15.5390 96.206 | 16 |
| 15 | 9 | Graham Rahal | 15 | United Rentals | Dallara UAK 18 | Honda | 100 | 1:52:16.2043 96.197 | 15 |
| 16 | 19 | Conor Daly | 20 | United States Air Force | Dallara UAK 18 | Chevy | 100 | 1:52:39.5718 95.864 | 14 |
| 17 | 10 | Álex Palou | 10 | NTT DATA | Dallara UAK 18 | Honda | 99 | Pulled in | 14 |
| 18 | 12 | James Hinchcliffe | 29 | Genesys | Dallara UAK 18 | Honda | 99 | Flagged | 12 |
| 19 | 6 | Patricio O'Ward | 5 | Arrow Electronics/Vuse | Dallara UAK 18 | Chevy | 99 | Flagged | 11 |
| 20 | 21 | Ed Jones | 18 | SealMaster | Dallara UAK 18 | Honda | 99 | Flagged | 10 |
| 21 | 11 | Alexander Rossi | 27 | AutoNation/NAPA Auto Parts | Dallara UAK 18 | Honda | 98 | Flagged | 9 |
| 22 | 23 | Jimmie Johnson | 48 | Carvana | Dallara UAK 18 | Honda | 95 | Flagged | 8 |
| 23 | 24 | Dalton Kellett | 4 | K-Line Insulators USA | Dallara UAK 18 | Chevy | 67 | Electrical | 7 |
| 24 | 22 | Max Chilton | 59 | Gallagher | Dallara UAK 18 | Chevy | 18 | Fuel fire | 6 |
| Lap Leaders | Total | Laps |
| Colton Herta | 97 | 1-34, 37-100 |
| Álex Palou | 2 | 36-37 |
| Simon Pagenaud | 1 | 35 |