Grand Prix of Portland
Portland International Raceway
1.964 Mile Road Course
110 Laps/216.04 Miles
September 12, 2021
| Finish | Start | Driver | Car # | Sponsor/Name | Chassis | Engine | Laps | Status | Points |
| 1 | 1 | Álex Palou | 10 | PNC Bank | Dallara UAK 18 | Honda | 110 | 2:07:04.1304 102.011 | 52 |
| 2 | 2 | Alexander Rossi | 27 | NAPA Auto Parts/AutoNation | Dallara UAK 18 | Honda | 110 | 2:07:05.4199 101.994 | 40 |
| 3 | 3 | Scott Dixon | 9 | PNC Bank | Dallara UAK 18 | Honda | 110 | 2:07:08.5710 101.951 | 36 |
| 4 | 20 | Jack Harvey | 60 | AutoNation/SiriusXM | Dallara UAK 18 | Honda | 110 | 2:07:12.3512 101.901 | 33 |
| 5 | 18 | Josef Newgarden | 2 | Hitachi | Dallara UAK 18 | Chevy | 110 | 2:07:13.0870 101.891 | 30 |
| 6 | 4 | Felix Rosenqvist | 7 | Vuse/Arrow Electronics | Dallara UAK 18 | Chevy | 110 | 2:07:13.4535 101.886 | 28 |
| 7 | 10 | Marcus Ericsson | 8 | Huski Chocolate | Dallara UAK 18 | Honda | 110 | 2:07:14.4729 101.873 | 27 |
| 8 | 6 | Colton Herta | 26 | Gainbridge | Dallara UAK 18 | Honda | 110 | 2:07:16.3932 101.847 | 24 |
| 9 | 15 | Scott McLaughlin | 3 | PPG | Dallara UAK 18 | Chevy | 110 | 2:07:18.0742 101.825 | 23 |
| 10 | 5 | Graham Rahal | 15 | Total | Dallara UAK 18 | Honda | 110 | 2:07:21.6753 101.777 | 23 |
| 11 | 8 | Ed Jones | 18 | SealMaster | Dallara UAK 18 | Honda | 110 | 2:07:22.2894 101.768 | 20 |
| 12 | 26 | Takuma Sato | 30 | Mi-Jack/Panasonic | Dallara UAK 18 | Honda | 110 | 2:07:22.8817 707.761 | 18 |
| 13 | 14 | Will Power | 12 | Verizon 5G | Dallara UAK 18 | Chevy | 110 | 2:07:23.9616 101.746 | 17 |
| 14 | 7 | Patricio O'Ward | 5 | Arrow Electronics/Vuse | Dallara UAK 18 | Chevy | 110 | 2:07:24.9798 101.733 | 17 |
| 15 | 27 | Ryan Hunter-Reay | 28 | DHL | Dallara UAK 18 | Honda | 110 | 2:07:29.6940 101.670 | 15 |
| 16 | 16 | Conor Daly | 20 | United States Air Force | Dallara UAK 18 | Chevy | 110 | 2:07:31.5276 101.646 | 14 |
| 17 | 25 | Rinus VeeKay | 21 | SONAX | Dallara UAK 18 | Chevy | 110 | 2:07:36.0765 101.585 | 13 |
| 18 | 12 | Sébastien Bourdais | 14 | ROKiT | Dallara UAK 18 | Chevy | 110 | 2:07:36.5563 101.579 | 12 |
| 19 | 11 | Max Chilton | 59 | Match Fit Pass | Dallara UAK 18 | Chevy | 110 | 2:07:37.4201 101.567 | 11 |
| 20 | 22 | Jimmie Johnson | 48 | Carvana | Dallara UAK 18 | Honda | 110 | 2:07:37.8330 101.562 | 10 |
| 21 | 23 | Simon Pagenaud | 22 | Menards | Dallara UAK 18 | Chevy | 109 | Flagged | 9 |
| 22 | 21 | Romain Grosjean | 51 | Nurtec ODT | Dallara UAK 18 | Honda | 95 | Flagged | 8 |
| 23 | 17 | Helio Castroneves | 06 | AutoNation/SiriusXM | Dallara UAK 18 | Honda | 91 | Flagged | 7 |
| 24 | 9 | Oliver Askew | 45 | Hy-Vee/Mountain Dew | Dallara UAK 18 | Honda | 89 | Wrecked | 6 |
| 25 | 19 | Callum Ilott | 77 | Dynamo Edge | Dallara UAK 18 | Chevy | 77 | Mechanical | 5 |
| 26 | 24 | Dalton Kellett | 4 | K-Line Insulators USA | Dallara UAK 18 | Chevy | 50 | Fuel injection | 5 |
| 27 | 13 | James Hinchcliffe | 29 | Capstone Turbine | Dallara UAK 18 | Honda | 1 | Wrecked | 5 |
| Lap Leaders | Total | Laps |
| Graham Rahal | 36 | 29-34, 34, 44-73 |
| Álex Palou | 29 | 43, 76-78, 86-110 |
| Patricio O'Ward | 28 | 1-28 |
| Jack Harvey | 5 | 37-39, 74-75 |
| Scott McLaughlin | 5 | 80-84 |
| Scott Dixon | 4 | 40-42, 79 |
| Ed Jones | 2 | 35-36 |
| Marcus Ericsson | 1 | 85 |